Relief of Pain and Inflammation : Gout
OALLO2 “Allopurinol tablet”100 mg/tab
OTONS1 “Tonsaric tablet”100 mg/tab
適應症：痛風症、痛風性關節炎、尿酸結石、癌症或經化學治療產生之高尿酸血症。
Usual dose:
Calcium renal calculus:
Adult: 200-300 mg qd or divided dose bid-tid, max. 300 mg/dose, 800 mg/day.
Cancer – Hyperuricemia:
Adult: 600-800 mg/day, 12 h-3 days prior to initiation of chemotherapy.
Pediatric (< 6 yrs): 50 mg tid.
Pediatric (6-10 yrs): 100 mg tid or 300 mg qd.
Gout (mild):
Adult: 100-300 mg/day qd or divided dose bid-tid.
Gout (moderate to severe):
Adult: 400-600 mg/day qd or divided dose bid-tid; max. 800 mg/day.
Dose adjustment:
Maintenance dose should be based on serum uric acid determinations performed 48 h after initial dose.
Renal impairment: CrCl 10-20 ml/min, 200 mg daily; CrCl 3-10 ml/min, 100 mg daily; CrCl < 3 ml/min, 100 mg at extended intervals > q24h.
Precaution:
Discontinue at first sign of allergic reaction.
During concommitant therapy, reduce doses of azathioprine and mercaptopurine to 1/3 to 1/4 of the usual dose.
Maintain fluid intake necessary to yield a daily urine output of at least 2 liters in adults.
Adverse effect:
Common: pruritus, rash, nausea, vomiting, renal failure
Serious: Stevens-Johnson syndrome, agranulocytosis, anemia, myelosuppression, hepatotoxicity.
健保使用規範：
2.11.2.含allopurinol成分製劑(105/2/1)
1.限使用於痛風症、痛風性關節炎、尿酸結石、癌症或經化學治療產生之高尿酸血症之治療。
2.本藥品可能發生嚴重藥物不良反應，故不得使用於非核准之適應症。且須充分提醒病人相關不良反應症狀及後續作為。