Psychopharmacologic Drugs : Antipsychotics
OAMIL2 “Amillian tablet” 200 mg/tab
OSOLI1 “Solian tablet” 200 mg/tab
適應症：精神分裂症。
Usual dose:
Acute psychotic episodes:
Adult (≧15 yrs): 400-800 mg/day, the daily dose may be increased up to 1200 mg/day, dose > 300 mg should be divided bid.
Negtive symptoms:
Adult (≧15 yrs): 50-300 mg/day.
Dose adjustment:
Renal insufficiency: CrCl 30-60 ml/min, reduce dose by 1/2; CrCl 10-30 ml/min, reduce dose to 1/3.
Contraindication:
Pheochromocytoma, prolactinomas and breast cancer, pregnancy, lactation, children < 15 yrs.
Adverse effect:
Insomnia, anxiety, agitation, extrapyramidal symptoms, galactorrhea, amenorrhea, gynecomastia, swollen breasts, impotence, frigidity, weight gain, GI disturbances, daytime drowsiness.
健保使用規範：
1.需合乎衛生主管機關許可之適應症範圍，並需符合下列條件 (1)開始使用「第二代抗精神病藥品」時需於病歷記載：醫療理由或診斷，以及臨床整體評估表(CGI)之分數；(2)經規則使用六至八週後，需整體評估其療效，並於病歷記載：臨床整體評估表之分數；(3)日劑量超過時800 mg/day，須於病歷記載理由。
2.本類藥品不得使用於雙極性疾患之鬱症發作。(95/10/1)