Cardiovascular – Renal Drugs: Antihypertensive: Calcium-Channel Blockers
OSEVI2 “Sevikar FC tablet”
Each tablet contains amlodipine besylate 6.94 mg (equivalent to amlodipine 5 mg), olmesartan medoxomil 20 mg
適應症：治療高血壓，此複方藥品不適合用於起始治療。
Usual dose:
Initial dose: amlodipine 5 mg/olmesartan 20 mg once daily; with dose titration occurring every 1 to 2 weeks, if necessary; max. amlodipine 10 mg/olmesartan 40 mg
Fixed dose, replacement therapy: initiate at dose of individually titrated components: amlodipine 5 mg/olmesartan 20 mg (5/20 mg) to max. 10/40 mg; may initiate dose increases after 2 weeks.
Add-on therapy: fixed dose amlodipine 5 mg/olmesartan 20 mg (5/20 mg) to max. 10/40 mg; may initiate dose increases after 2 weeks.
Precaution:
Fetal injury or death may occur with use during pregnancy; discontinue immediately if pregnancy occurs.
Adverse effect:
Common: Edema, dizziness (amlodipine besylate, 3.4%; olmesartan medoxomil, 3% ), headache.
Serious: Disorder of intestine, sprue-like cholestasis; hepatitis, anaphylaxis, rhabdomyolysis, acute renal failure, angioedema.