Amlodipine & olmesartan medoxomil & hydrochlorothiazide 【C (1st trimester), D (2nd, 3rd trimester)】

Cardiovascular – Renal Drugs : Antihypertensive: Calcium-Channel Blockers
OSEVI3 “Sevikar HCT tablet

Each tablet contains amlodipine besylate 6.94 mg (equivalent to amlodipine 5 mg), olmesartan medoxomil 20 mg, hydrochlorothiazide 12.5 mg

適應症:治療高血壓。本品適用於以olmesartan、amlodipine、hydrochlorothiazide其中兩種成分合併治療,仍無法有效控制血壓的高血壓病患。

Usual dose:

initiate at dose of individually titrated components: olmesartan 20 mg/amlodipine 5 mg/hydrochlorothiazide 12.5 mg to max. olmesartan 40 mg/amlodipine 10 mg/hydrochlorothiazide 25 mg once daily; after 2 weeks, may increase dose 1 component at a time.

Precaution:

May cause fetal and neonatal morbidity and mortality; discontinue use immediately when pregnancy confirmed

Adverse effect:

Common: Peripheral edema, diarrhea, nausea, joint swelling, spasm, dizziness, headache, urinary tract infectious disease, nasopharyngitis, upper respiratory infection, fatigue.

Serious: Disorder of intestine, sprue-like; angle-closure glaucoma, acute; myopia, acute transient; renal failure.

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