Cardiovascular – Renal Drugs : Antihypertensive: Calcium-Channel Blockers
OSEVI3 “Sevikar HCT tablet”
Each tablet contains amlodipine besylate 6.94 mg (equivalent to amlodipine 5 mg), olmesartan medoxomil 20 mg, hydrochlorothiazide 12.5 mg
適應症：治療高血壓。本品適用於以olmesartan、amlodipine、hydrochlorothiazide其中兩種成分合併治療，仍無法有效控制血壓的高血壓病患。
Usual dose:
initiate at dose of individually titrated components: olmesartan 20 mg/amlodipine 5 mg/hydrochlorothiazide 12.5 mg to max. olmesartan 40 mg/amlodipine 10 mg/hydrochlorothiazide 25 mg once daily; after 2 weeks, may increase dose 1 component at a time.
Precaution:
May cause fetal and neonatal morbidity and mortality; discontinue use immediately when pregnancy confirmed
Adverse effect:
Common: Peripheral edema, diarrhea, nausea, joint swelling, spasm, dizziness, headache, urinary tract infectious disease, nasopharyngitis, upper respiratory infection, fatigue.
Serious: Disorder of intestine, sprue-like; angle-closure glaucoma, acute; myopia, acute transient; renal failure.