Anti-infective Agents : Penicillins
ISUBA1 “Subacillin injection”
Each ml contains ampicillin sodium 1 gm, sulbactam sodium 0.5 gm; 1.5 gm/vial
IUNAS1 “Unasyn injection”
Each ml contains ampicillin sodium 1 gm, sulbactam sodium 0.5 gm; 1.5 gm/vial
適應症：鏈球菌、葡萄球菌、大腸桿菌、克雷氏菌、沙雷氏菌、流行感冒嗜血桿菌、陰性變形桿菌屬、檸檬酸菌屬、厭氧性細菌(Bacteroides fusobacterium, Clostridium difficile)，Branhamella catarrhalis引起之感染症。
Usual dose:
Susceptible infections: IV/ IM
Adult: 1.5-3 g (1-2 g ampicillin and 0.5-1 g sulbactam) q6h; max. 4 gm sulbactam/day.
Pediatric: 25-50 mg/kg (ampicillin component) q6h; max. 4 gm sulbactam/day.
Meningitis: IV/IM
Pediatric: 200-400 mg/kg/day (ampicillin component) divided q4-6h; max. 4 g sulbactam/day.
Dose adjustment:
Renal failure: CrCl 20-40 ml/min, 2.25 mg q6h; CrCl < 20 ml/min 2.25 mg q8h.
Hemodialysis: max. 2.25 gm q8h; (0.75 g after each dialysis session).
Adverse effect: injection site reaction, rash, diarrhea.
健保使用規範：單次注射劑處方劑量為1.5公克時，不得以0.75公克兩瓶申報。