Anti-infective Agents : Sulfonamides, Sulfones and Trimethoprim
ISEVA1 “Sevatrim injection”
Each ml contains sulfamethoxazole 80 mg, trimethoprim 16 mg; 5 ml/amp
OMORC1 “Morcasin tablet”
Each tablet contains sulfamethoxazole 400 mg, trimethoprim 80 mg
適應症：
ISEVA1：由革蘭氏陽性菌及陰性菌所引起之呼吸道、胃腸道、尿道感染症。
OMORC1：葡萄狀球菌、鏈鎖球菌、肺炎雙球菌、大腸菌、赤痢菌及綠膿菌引起之感染症。
Usual dose:
Adult: 2 tab PO q12h.
Pediatric (> 2 mon): 8 mg/kg TMP component/day divided q12h.
Pneumocystis carinii pneumonia: 15-20 mg/kg TMP component/day divided q6h.
Bacteremia associated with intravascular line (due to Stenotrophomonas maltophilia, Burkholderia cepacia, and Ochrobacterium anthropi):
Adult: 3-5 mg/kg trimethoprim component IV q8h.
Bacterial meningitis:
Adult: 10-20 mg/kg trimethoprim component/day IV divided q6-12h.
Pneumocystis pneumonia:
Pediatric (> 2 mon): 15-20 mg/kg/day trimethoprim component IV in 3-4 divided doses infused over 1 h for 21 days; may switch to oral at same dose when appropriate.
Bacterial meningitis:
Pediatric (infants and children > 28 days): 10-20 mg/kg trimethoprim component/day IV divided q6-12 h.
Dose adjustment:
Renal failure: CrCl 15-30 ml/min, give one-half the usual dose; CrCl < 15 ml/min, not recommended.
Contraindication:
Infants < 2 mon; PCP prophylaxis can begin at 1 mon of age, pregnant p’ts atia due to folate deficiency.
Adverse effect:
Common: rash, urticaria, loss of ap term, nursing mothers, megaloblastic anem petite, nausea, vomiting.
Serious: agranulocytosis, aplastic anemia, disease of hematopoietic system, hepatic necrosis, fulminant, allergic reaction, Stevens-Johnson syndrome, toxic epidermal necrolysis.