Cardiovascular – Renal Drugs : Antihypertensive : Sympathetic Depressants
OBISO4 “Bisol FC tablet” 5 mg/tab
OBISO9 “Bisol tablet” 1.25 mg/tab
OCONC1 “Concor FC tablet” 5 mg/tab
OCONC3 “Concor FC tablet” 1.25 mg/tab
適應症：
OBISO4, OCONC1：狹心症、高血壓、穩定型慢性中度至重度心衰竭（NYHA class III、IV）。
OBISO9, OCONC3：穩定型慢性中度至重度心衰竭。
Usual dose:
Angina: 5-20 mg qd.
Congestive heart failure: initial, 1.25 mg qd, titrate to max. 10 mg qd.
Hypertension: initial, 2.5-5 mg qd; maintenance, 2.5-20 mg qd, max. 40 mg qd.
Dose adjustment:
Renal impairment, hepatic failure: initial, 2.5 mg qd, max. 10 mg qd.
Contraindication:
Cardiogenic shock, overt cardiac failure, second and third degree AV block, severe sinus bradycardia.
Adverse effect:
Common: bradyarrhythmia, cold extremities, hypotension, diarrhea, indigestion, nausea, vomiting, arthralgia, dizziness, headache, dyssomnia, cough, dyspnea, pharyngitis, rhinitis, sinusitis, upper respiratory infection, fatigue.
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