Psychopharmacologic Drugs : Anxiolytics, Sedatives and Hypnotics
OFRIS2 “Frisium tablet” 10 mg/tab
適應症：焦慮狀態、癲癇症之輔助治療。
Usual dose:
Anxiety:
20 to 80 mg/day ORALLY (single or divided doses).
Lennox-Gastaut syndrome – Seizure; adjunct:
(Greater than 30 kg) Initial, 10 mg ORALLY daily (in 2 divided doses), titrate to 20 mg daily (2 divided doses) on day 7 and to 40 mg daily (2 divided doses) on day 14.
(30 kg or less) Initial, 5 mg ORALLY daily (in 2 divided doses), titrate to 10 mg daily (2 divided doses) on day 7 and to 20 mg daily (2 divided doses) on day 14.
Withdrawal of therapy, gradually decrease the total daily dose by 5 to 10 mg on a weekly basis until discontinued.
Dose adjustment:
Hepatic impairment (Child-Pugh score 5 to 9), geriatric: initial, 5 mg ORALLY once daily, titrated no faster than every 7 days to 10 to 20 mg/day in 2 divided doses depending on weight; if tolerated may titrate to max dose of 20 to 40 mg/day depending on weight starting on day 21.
Adverse effect:
Common: constipation, drooling, ataxia, dysarthria, insomnia, lethargy, sedated, somnolence aggressive behavior, urinary tract infectious disease, cough, fever.
Serious: Stevens-Johnson syndrome, toxic epidermal necrolysis.