Anti-infective Agents : Antiretroviral Agents
OCOMB2 “Combivir tablet”
Each tablet contains lamivudine 150 mg, zidovudine 300 mg
適應症：可單獨使用或與其他抗反轉錄病毒劑併用、來治療HIV感染的成人及十二歲以上的兒童。
Usual dose:
HIV infection, in combination with other antiretrovirals:
Adult: 1 tab bid.
Pediatric (≧12yrs): 1 tab bid.
Dose adjustment:
Renal failure: CrCl≦50 ml/min, not recommended.
Contraindication:
Fixed-dose combination in p’ts requiring dosage adjustment, concomitant use with stavudine, doxorubicin, or ribavirin; possible zidovudine antagonists.
Adverse effect:
Common: diarrhea, nausea, vomiting, musculoskeletal pain, headache, neuropathy, fatigue.
Serious:Lactic acidosis, anemia, neutropenia, hepatomegaly, steatosis of liver, drug-induced myopathy, myositis.
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