Hormones and Agents Affecting Hormonal Mechanism: Antidiabetic Agents: Oral Hypoglycemic Agents
OFORX1 “Forxiga tablet” 10 mg/tab
適應症：第二型糖尿病。
Usual dose: initial, 5 mg ORALLY QD in the morning; may increase to 10 mg QD.
Dose Adjustments
Renal impairment, mild (estimated GFR [eGFR] ≧60 mL/min/1.73 m2): No adjustment necessary.
Renal impairment, eGFR < 60 mL/min/1.73 m2 : Do not initiate therapy; use not recommended if eGFR is persistently between 30- 60 mL/min/1.73 m2..
Renal impairment, severe (eGFR < 30 mL/min/1.73 m2 ), ESRD, or receiving dialysis: Use contraindicated.
Hepatic impairment, Geriatric patients : No adjustment necessary.
Concomitant use of insulin or insulin secretagogues: Dose reduction of insulin or insulin secretagogues may be necessary to avoid hypoglycemia.
Contraindication:
Dialysis, end-stage renal disease. Renal impairment, severe (estimated GFR <30 mL/min/1.73 m2)
Adverse effect:
Common: urinary tract infectious disease, female genital infection, nasopharyngitis.
Serious: hypotension, diabetic ketoacidosis, hypoglycemia, ketoacidosis, hypersensitivity reaction, fracture of bone, bladder cancer, injury of kidney, pyelonephritis, renal impairment, urosepsis, volume depletion, renal, due to output loss (renal deficit), genital infection.
健保使用規範：每日限處方1粒（105/5/1）。