Hormones and Agents Affecting Hormonal Mechanism : Anterior Pituitary and Hypothalanic Function
IMINI1 “Minirin injection” 4 mcg/ml; 1 ml/amp
OMINI2 “Minirin tablet” 0.1 mg/tab
適應症：
IMINI1：中樞性尿崩症、本劑可能增加輕度及中度血友病患第八因子濃度。
OMINI2：中樞尿崩症，原發性夜尿症（限用於７歲以上病患），成人因夜間多尿所導致之夜尿症。
Usual dose:
Primary nocturnal enuresis: PO
Adult (≧7 yrs): initial, 0.2 mg hs; dose may be titrated up to 0.6 mg if necessary.
Neurohypophyseal diabetes insipidus: IV/SC
Adult (≧12 yrs): 2-4 mcg/day in 2 divided doses; comparable antidiuretic dose of the injection is about 1/10 of the intranasal dose.
Neurohypophyseal diabetes insipidus: PO
Adult (≧7 yrs): initial, 0.05 mg (1/2 of the 0.1 mg tablet) bid; maintenance, 0.1-0.8 mg/day in divided doses.
Contraindication: hyponatremia, existing or history; renal impairment, moderate to severe (CrCl < 50 ml/min).
Adverse effect:
Common: flushing, nausea, fatigue, headache.
Serious: abnormal blood pressure, increased heart rate, hyponatremia, hyposmolality, water intoxication syndrome, thromboembolic disorder, acute allergic reaction, anaphylaxis, seizure.