Relief of Pain and Inflammation : Non-Steroidal Anti-inflammatory Agents (NSAID)
OVORE1 “Voren EMC capsule” 50 mg/cap
TVORE3 “Voren suppository” 12.5 mg/supp
適應症：緩解發炎及因發炎反應引起之疼痛。
Usual dose:
Osteoarthritis: PO
Adult: 100-150 mg/day bid-tid, max. 200 mg/day.
Rheumatoid arthritis: PO
Adult: 100-200 mg/day tid-qid, max. 225 mg/day.
Ankylosing spondylitis: PO
Adult: 25 mg qid with an extra 25 mg dose hs if necessary.
Pain: PO
Adult: 75-150 mg/day in divided doses.
Fever: Rectal
Pediatric
(2-5 yrs): 25 mg prn.
(6-10 yrs): 50 mg prn.
Dose adjustment:
Renal impairment: initiate therapy with lowest recommended dosage, monitor p’ts closely.
Contraindication: See Diclofenac Potassium.
Adverse effect:
Common: edema, application site reaction, rash, abdominal pain, constipation, diarrhea, flatulence, indigestion, nausea, increased liver function test, dizziness, headache, burning sensation in eye, ophthalmic solution, conjunctivitis, corneal deposit, corneal edema, ophthalmic solution, corneal lesion, corneal opacity, discharge from eye, finding of lacrimation, iritis, ophthalmic solution, raised intraocular pressure, tinnitus, burning sensation.
Serious: congestive heart failure, hypertension, myocardial infarction, thrombotic tendency observations, erythema multiforme, generalized exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, gastrointestinal hemorrhage, gastrointestinal perforation, gastrointestinal ulcer, inflammatory disorder of digestive tract, melena, pancreatitis, vomiting, agranulocytosis, anemia, aplastic anemia, hemolytic anemia, leukopenia, purpuric disorder, thrombocytopenia, cirrhosis of liver, hepatic necrosis, hepatitis, jaundice, liver failure, anaphylactoid reaction, aseptic meningitis, cerebrovascular accident, seizure, blurred vision, hearing loss, acute renal failure, interstitial nephritis, nephrotic syndrome, proteinuria, bronchospasm, angioedema.