Anti-infective Agents : Antiretroviral Agents
OVIDE2 “Videx EC delayed-release capsule” 250 mg/cap
OVIDE3 “Videx EC delayed-release capsule” 400 mg/cap
適應症：治療受HIV感染的成人患者。
Usual dose:
HIV infection:
Adult (< 60 kg): 250 mg qd; (≧60 kg) 400 mg qd.
Pediatric (6-18 yrs, 20 kg -25 kg): 200 mg qd; (25 kg- 60 kg): 250 mg qd; (> 60 kg): 400 mg qd.
Dose adjustment:
Renal failure
(≧60 kg, CrCl 30-59 ml/min): 200 mg qd;
(≧60 kg, CrCl 10-29 ml/min): 125 mg qd.
(≧60 kg, < 10 ml/min): 125 mg qd.
(< 60 kg, CrCl 30-59 ml/min): 125 mg qd.
(< 60 kg, CrCl 10-29 ml/min): 125 mg qd.
(< 60 kg, CrCl < 10 ml/min): not recommended.
Adverse effect:
Common: rash, increase in body fat, lipodystrophy, shivering, abdominal pain, diarrhea, nausea, vomiting, asthenia, headache, fever.
Serious:lactic acidosis, pancreatitis, hepatomegaly, steatosis of liver, peripheral neuropathy, optic neuritis, retinal disorder.
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