Psychopharmacologic Drugs : Affective Disorders
ODOXE1 “Doxepin capsule ” 25 mg/cap
適應症：焦慮狀態、憂鬱病。
Usual dose:
Anxiety-Depression:
Adult ( > 12 yrs): (very mild) 25-50 mg/day, (mild- moderate) 75 mg/day in single or divided doses, increase as needed; max. 300 mg/day.
Dose adjustment:
Geriatric: 25-50 mg/day.
Liver disease: begin with low initial doses.
Contraindication: glaucoma, urinary retention.
Precaution:
Concomitant use of MAOIs or use of doxepin within 14 days of MAOI discontinuation.
Adverse effect:
Common: weight gain, bloating symptom, constipation, xerostomia, dizziness, somnolence, blurred vision, urinary retention.
Serious: hypertension, hypotension, tachyarrhythmia, agranulocytosis, leukopenia, pancytopenia, purpuric disorder, thrombocytopenia, depression, worsening, suicidal thoughts, suicide.
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