Anti-infective Agents : Antiretroviral Agents
ODUOV1 “Duovir-N FC tablet”
Each tablet contains lamivudine 150 mg, zidovudine 300 mg, nevirapine 200 mg
適應症：治療愛滋病毒HIV-1感染，用於已在接受lamivudine、zidovidine及nevirapine 各單方相同劑量合併治療且可耐受的成人病患。
Usual dose:
HIV infection, in combination with other antiretrovirals:
Adult: 1 tab bid.
Pediatric (≧12yrs): 1 tab bid.
Dose adjustment:
Renal failure: CrCl≦50 ml/min, not recommended.
Contraindication:
Fixed-dose combination in p’ts requiring dosage adjustment, concomitant use with stavudine, doxorubicin, or ribavirin; possible zidovudine antagonists.
Adverse effect:
Common: diarrhea, nausea, vomiting, musculoskeletal pain, headache, neuropathy, fatigue.
Serious:Lactic acidosis, anemia, neutropenia, hepatomegaly, steatosis of liver, drug-induced myopathy, myositis.
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