Cardiovascular – Renal Drugs : Antihypertensive : Angiotensin-converting Enzyme Inhibitors (ACEI)
OSYNB2 “Synbot tablet” 5 mg/tab
適應症：高血壓、充血性心臟衰竭。
Usual dose:
Congestive heart failure:
Adult: initial, 2.5 mg qd or bid; maintenance, 2.5-20 mg bid; max. 20 mg daily in divided doses.
Pediatric (≧4 yrs): 0.1-0.5 mg/kg qd or in 2 divided doses, max. 0.94 mg/kg/day.
Hypertension:
Adult: initial, 5 mg qd; maintenance, 10-40 mg qd or in 2 divided doses.
Pediatric (1 mon-16 yrs): initial, 0.08 mg/kg qd (up to 5 mg), max. 0.58 mg/kg or 40 mg/day.
Kidney disease, Nondiabetic:
Adult: initial, 5 mg qd; maintenance, 5-20 mg qd, max. 20 mg/day.
Dose adjustment:
Renal impairment: hypertension with renal impairment: CrCl≦30 ml/min (serum creatinine≧3 mg/dL), starting dose 2.5 mg qd; titrate to effect, max. 40 mg/day.
CHF with renal impairment or hyponatremia: starting dose 2.5 mg qd; titrate at 4-day intervals to 2.5 mg bid, then 5 mg bid, max. 40 mg/day.
Contraindication:
Angioedema, hereditary or idiopathic, angioedema related to prior therapy with an ACE inhibitor.
Adverse effect:
Common: hypotension, rash, hyperkalemia, nausea and vomiting, asthenia, dizziness, cough.
Serious: syncope, intestinal angioedema, liver failure, angioedema in face, lips, throat.