Neurologic Drugs : Parkinsonism
OCOMT1 “Comtan FC tablet” 200 mg/tab
適應症：併用levodopa & benserazide或者levodopa & carbidopa兩類藥品治療帕金森氏症病人。
Usual dose:
Parkinson’s disease; Adjunct:
Adult: 200 mg with each dose of levodopa/carbidopa, max. 1600 mg/day.
Precaution:
Concomitant non-selective MAOIs, drugs known to be metabolized by COMT (eg, isoproterenol, epinephrine, norepinephrine, dopamine, dobutamine, alpha-methyldopa, apomorphine, isoetharine, bitolterol), drugs that interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase (ie, probenecid, cholestyramine, and some antibiotics: erythromycin, rifampicin, ampicillin, chloramphenicol).
Adverse effect:
Common: abdominal pain, constipation, diarrhea, nausea, vomiting, dizziness, discolored urine, fatigue.
Serious: dyskinesia, hyperactive behavior, hallucinations.
健保使用規範：同amantadine.