Hormones and Agents Affecting Hormonal Mechanism : Anterior Pituitary and Hypothalanic Function
IGONA4 “Gonal-F injection” 450 IU/0.75 mL/vial
IGONA2 “Gonal-F injection” 75 IU(5.5 mcg)/amp
適應症：(1)婦女經CLOMIPHENE CITRATE治療，仍無法排卵者(含多囊性卵巢症，PCOD) 。(2)對於實施人工生殖協助技術(ART)，如體外受精(IVF)，配子輸卵管植入(GIFT)，合子輸卵管植入(ZIFT)的病人，可刺激其多濾泡發育。(3)與黃體刺激素(LH)併用，使用於嚴重缺乏黃體刺激激素與濾泡刺激激素患者的濾泡刺激成長。
Usual dose: SC
Female infertility: 150 IU daily in early follicular phase, until sufficient follicular development; MAX duration 10 days; administer hCG once follicular development is evident;(over 35 years with suppressed gonadotropin levels) 225 IU daily until adequate follicular development; may adjust dose after 5 days in 75 to 150 IU increments at 3 to 5 day intervals; MAX dose 450 IU/day; administer hCG once follicular development is evident.
Spermatogenesis induction: following hCG pretreatment, 150 IU 3 times a week up to 18 months; dose may be increased to MAX 300 IU 3 times a week; administer with hCG
Ovulation induction: initial, 75 IU daily; may increase dose by 37.5 IU after 14 days, depending on response; additional adjustments, if needed, every 7 days; MAX dose 300 IU/day, MAX duration 35 days; administer hCG 1 day after last dose.
Contraindication:
Abnormal uterine bleeding of undetermined origin, , organic intracranial lesion (pituitary tumor), ovarian cyst or enlargement of undetermined origin, sex hormone dependent tumors of the reproductive tract and accessory organs, uncontrolled thyroid or adrenal dysfunction.
Adverse effect:
Common: abdominal pain, nausea, headache, cyst of ovary.
Serious: atelectasis, ovarian hyperstimulation syndrome, abnormal vaginal bleeding, arterial thromboembolism, acute respiratory distress syndrome.
健保使用規範：FSH (pure FSH)用於誘發排卵時，限hypothalamus failure（下視丘功能衰竭）患者，事前專案報准後使用(85/1/1)。