Cardiovascular – Renal Drugs : Diuretics
IRASI1 “Rasitol injection” 20 mg/ 2 ml; 2 ml/amp
IROSI1 “Rosis injection” 20 mg/ 2 ml; 2 ml/amp
OFUMI1 “Fumide Oral Solution” 10 mg/ml; 120 ml/bot
OURET1 “Uretropic table” 40 mg/tab
適應症：
IRASI1, IROSI1：利尿、高血壓、急性肺水腫。
OFUMI1, OURET1：利尿、高血壓。
Usual dose:
Edema:
Initial, 20 to 80 mg orally daily, may repeat in 6 to 8 hours; max. 600 mg/day orally.
Titrate to maintenance, may increase by 20 to 40 mg orally at 6- to 8-hour intervals after the previous dose; this individual dose may be given once or twice daily; max. 600 mg/day orally
Hypertension: Initial, 80 mg orally daily (divided twice daily)
Dose adjustment:
Liver disease: cirrhotic patients have a diminished diuretic effect and may require a higher than usual dose (specific guidelines unavailable)
Renal failure, chronic: initial, 80 to 120 mg orally daily; max. 1500 mg orally daily.
Contraindication: Anuria, history of hypersensitivity to furosemide.
Precaution:
Black box warning: Profound diuresis may cause water and electrolyte depletion, dehydration, and blood volume reduction; monitoring recommended.
Adverse effect:
Common: hyperuricemia (40%), hypomagnesemia, loss of appetite, spasm of bladder.
Serious: orthostatic hypotension, drug hypersensitivity syndrome, erythema multiforme, erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis due to drug, pancreatitis, agranulocytosis, aplastic anemia, thrombocytopenia, anaphylactoid reaction, anaphylaxis.
