Levofloxacin【C】

Anti-infective Agents : Quinolones
ICRAV2 “Cravit IV Sol’n injection” 5 mg/ml; 50 ml/bot
OCRAV2 “Cravit FC tablet” 500 mg/tab
OLEFL1 “Leflodal FC tablet” 500 mg/tab
IBACF1 “Bacflocin IV Sol’n injection” 5 mg/ml; 50 ml/bot

適應症:

ICRAV2, IBACF1:治療成人因對 LEVOFLOXACIN有感受性的致病菌所引起之下列感染社區性肺炎、複雜性尿道感染(包括:腎盂腎炎),皮膚和軟組織感染。慢性細菌性前列腺炎。

OCRAV2, OLEFL1:治療成人因對levofloxacin有感受性的致病菌所引起之下列感染:急性鼻竇炎、慢性支氣管炎的急性惡化、社區性肺炎、複雜性泌尿道感染(包括:腎盂腎炎)、皮膚和軟組織感染。

Usual dose: PO/IV

Susceptible infection: 500-750 qd.

UTI: 250 mg qd.

Precaution:

IV, infuse over at least 60 min (250 mg and 500 mg) or 90 min (750 mg).

Oral tablets, may take with or without food, do not give within 2 h of antacids, sucralfate, iron.

Dose adjustment:

Renal failure:

CrCl 20-49 ml/min, 750 mg initially then 750 mg q48h; CrCl 10-19 ml/min, 750 mg initially then 500 mg q48h; hemodialysis/CAPD, 750 mg initially then 500 mg q48h.

Inhalational anthrax: CrCl 20-49 ml/min, 500 mg initially then 250 mg q24h; CrCl 10-19 ml/min, 500 mg initially then 250 mg q48h; hemodialysis/CAPD, 500 mg initially then 250 mg q48h.

UTI: CrCl 10-19 ml/min, 250 mg initially then 250 mg q48h.

Adverse effect:

Common: injection site reaction, diarrhea, nausea, headache.

Serious: torsades de pointes, hyperglycemia, hypoglycemia, usually in diabetic p’ts, hypersensitivity reaction, rupture of tendon.

健保使用規範:限用於成人(18歲以上)之慢性支氣管炎的急性惡化、社區性肺炎、複雜性泌尿道感染。若使用於結核病不予給付。

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