Cardiovascular – Renal Drugs : Antihypertensive : Angiotensin II Antagonist (ARB)
OHYSA1 “Hysartan tablet” 50/12.5mg
Each tablet contains losartan 50 mg, hydrochlorothiazide 12.5 mg
OHYZA2 “Hyzaar FC tablet”
Each tablet contains losartan potassium 100 mg, hydrochlorothiazide 12.5 mg
適應症：高血壓。
Usual dose:
Adult: initial and mantain dose, 1 tab daily. Max. 2 tab daily.
Dose adjustment:
Hepatic impairment and renal impairment(creatinine clearance < 30 ml/min) are not recommended.
Contraindication:
Anuria, allerge to sulfonamide, concomitant use with aliskiren in patients with diabetes.
Precaution:
Angioedema (associated with aspirin and/or penicillin allergy), breast feeding period, geriatrics, liver disease, pregnancy (particularly 2nd-3rd trimesters), renal impairment.
Adverse effect:
Common: chest pain, hypotension, hyperkalemia, hypoglycemia, diarrhea, anemia, asthenia, dizziness, cough, fatigue.
Serious: hepatotoxicity, rhabdomyolysis, acute renal failure, angioedema.