Cardiovascular – Renal Drugs : Hyperlipidemia
OSANC2“Sancos tablet” 20 mg/tab
ODELI1 “Delipic tablet” 20 mg/tab
適應症：高膽固醇血症、高三酸甘油脂血症。
Usual dose:
Atherosclerosis, Hypercholesterolemia, Coronary heart disease, prophylaxis:
Adult: initial, 20 mg qd; maintenance, 10-80 mg qd or in 2 divided doses; max. 80 mg/day.
Hypercholesterolemia, heterozygous familial:
Adult: initial, 20 mg qd; maintenance, 10-80 mg qd or in 2 divided doses; max. 80 mg/day.
Pediatric(10-17 yrs): initial 10 mg daily; max. 40 mg/day.
Dose adjustment:
Renal impairment: CrCl < 30ml/min, doses > 20 mg/day- give with caution.
Concomitant use with cyclosporine, gemfibrozil, other fibrates, or niacin (> 1 g/day): initial, 10 mg/day; max. 20 mg/day.
Concomitant use with amiodarone or verapamil: max. 40 mg/day.
Contraindication: active liver disease, pregnancy and lactation, concomitant use with cyclosporine/ gemfibrozil/ strong CYP3A4 inhibitors.
Adverse effect:
Common: arthralgia, abdominal pain, constipation.
Serious: dermatomyositis, increased liver enzymes, liver failure, autoimmune disease, systemic lupus, erythematosus, disorder of muscle, rhabdomyolysis, rupture of tendon.
健保使用規範：同atorvastatin。