Antidotes in Poisoning : Specific Antidotes
IUROM1 “Uromitexan injection” 100 mg/ml; 4 ml/vial
TMESA1 “Mesa inhalation solution 200 mg/ml; 3 ml/amp
TSIRU1 “Siruta inhalation solution” 200 mg/ml; 3 ml/amp
適應症：
IUROM1：尿路保護劑-防止Oxazaphosphorines類藥物所引起出血性膀胱發炎。
TMESA1, TSIRU1：支氣管障礙之化痰。
Usual dose:
Hemorrhagic cystitis prophylaxis-continuous IV:
Bolus dose (20% total ifosfamide dose), then 40% of ifosfamide CIV.
Hemorrhagic cystitis prophylaxis:
IV bolus 20% of ifosfamide dose (W/W) at 0, 4, 8 h.
Mucolytic: Inhalation, 1-2 amp each time, qd-qid.
Contraindication: hypersensitivity to mesna or any component of the product.
Precaution:
Dermatologic toxicity, including symptoms consistent with drug reaction with eosinophilia and systemic (DRESS), Stevens-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN); discontinue and institute appropriate care if occurs.
Infants and neonates, premature or low-birthweight (unapproved use); avoid use; injection solution contains benzyl alcohol.
Adverse effect:
Common: nausea, vomiting, headache, pain in limb, fatigue.
Serious: hypotension.
健保使用規範：限癌症或骨髓移植病例使用大量endoxan；ifosphamide類藥物時使用。