Hormones and Agents Affecting Hormonal Mechanism: Antidiabetic Agents: Oral Hypoglycemic Agents
OGLUC2 “Glucomine FC tablet” 250 mg/tab
OCTL1 “C.T.L XR tablet” 500 mg/tab
OEUTO1 “Eutomin tablet” 850 mg/tab
OGLUC5 “Glucophage tablet” 850 mg/tab
適應症：
OCTL1：治療第II型糖尿病。
OEUTO1, OGLUC2, OGLUC5：糖尿病。
Usual dose:
Diabetes mellitus type II: initial, 500 mg bid or 850 mg qd; maintenance, titrate in 500 mg increments weekly or 850 mg increments every 2 weeks; max. 3000 mg/day.
Dose adjustment:
Renal impairment: eGFR: 30-45 ml/min/1.73 m2: titrated to the minimum dose for adequate glycemic effect.
Contraindication: eGFR< 30 ml/min/1.73 m2 (or Scr≧ 1.5 mg/dL [males] or 1.4 mg/dL [females] or an abnormal CrCl); iodinated contrast media (usually used in X-ray examination); metabolic acidosis including ketoacidosis; Elderly (age>80y).
Adverse effect:
Common: diarrhea, nausea, vomiting, flatulence, cobalamin deficiency, malabsorption syndrome, asthenia, indigestion, headache.
Serious: Lactic acidosis (Rare), hepatitis.