Hormones and Agents Affecting Hormonal Mechanism : Anterior Pituitary and Hypothalanic Function
IMETH6“Methylprednisolone injection” 40 mg/vial【C】
OMETI1“Metisone tablet” 4 mg/tab【A】
適應症：
IMETH6:腎上腺皮質機能不全，劇烈 休克、支氣管性氣喘、膠原疾病、過敏反應、泛發性感染。
OMETI1:風濕性熱、風濕樣關節炎及過敏性症狀。
Usual dose:
IV/IM/IF over 30 min.
Adult: 10-250 mg up to 6 times/day.
High dose therapy: IV, 30mg/kg over at least 30 min q4h, not beyond 48-72 h.
Anti-inflammatory and Immunosuppressant: PO
Adult: 4-48 mg/day divided in 1-4 doses.
Pediatric: 0.5-2 mg/kg/day divided q6-12h.
Multiple sclerosis: PO
Adult: 160 mg daily for 1 wk, 64 mg qod for 1 mo.
Pediatric: 0.5-1.7 mg/kg/day in 2-4 divided doses.
Contraindication: systemic fungal infections.
Adverse effect:
Common: hypertension, atrophic condition of skin, finding of skin healing impaired, decreased body growth, disorder of gastrointestinal tract, at risk for infection, depression, euphoria.
Serious: cushing’s syndrome, hyperglycemia, primary adrenocortical insufficiency, osteoporosis, cataract, glaucoma, pulmonary tuberculosis.
Dose Adjustments:
renal: dose adjustment not necessary;obesity: calculate dose according to ideal body weight and consider an increased dosing interval ;exposure to stress: dose reductions may be required ;concomitant CYP3A4 inducers: corticosteroid dose increases may be required.