Neostigmine methylsulfate【C】

Neurologic Drugs : Anesthesia
IVAGO1 “Vagostin injection” 0.5 mg/ml; 1 ml/amp
INEOS1 “Neostigmine injection” 0.5 mg/ml; 1 ml/amp

適應症:各種腸管麻痺及排尿困難。由於肌無力、肌肉麻痺、腦溢血、小兒麻痺、神經痛、關節痛等引起之各種運動障礙。眼肌無力症、綠內障、瞳孔反應檢查等。

Usual dose:

Myasthenia gravis: IM/SC, 0.5 mg.

Urinary retention: IM/SC

Initial, 0.5 mg. after the bladder is emptied continue 0.5 mg q3h for at least 5 doses.

Prophylaxis for post-operative urinary retention: IM/SC

0.25 mg after the operation. This dose may be repeated q4-6h for 2-3 days.

Reversal of neuromuscular blockade: slow IV injection

Adult: 0.5-2 mg slowly, repeat as needed.

Pediatric: 0.025- 0.1 mg/kg/dose IV with atropine or glycopyrrolate.

Contraindication: intestinal or urinary obstruction, peritonitis.

Adverse effect:

Common: excessive salivation, muscle fasciculation.

Serious: atrial fibrillation, atrioventricular block, bradyarrhythmia, cardiac arrest, cardiac dysrhythmia, loss of consciousness, seizure, bronchospasm, respiratory arrest, respiratory depression.

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