Cardiovascular – Renal Drugs : Antihypertensive : Angiotensin-converting Enzyme Inhibitors (ACEI)
OACER2 “Acertil FC tablet” 5 mg/tab
適應症：高血壓、充血性心臟衰竭、對於有心肌梗塞及/或血管重建病史的病人，併用傳統心絞痛治療藥物，可降低心臟事件的危險。
Usual dose:
Cardiovascular event risk, Stable coronary artery disease; Prophylaxis:
Initial, 4 mg qd for 2 wks; increase as tolerated, maintenance, 8 mg qd.
Hypertension:
Initial, 4 mg qd; concomitant diuretic therapy: the diuretic should be discontinued 2-3 days prior to initiating perindopril, if the diuretic cannot be discontinued, the starting dose of perindopril should be 2-4 mg qd or in 2 divided doses, maintenance, 4-8 mg qd or in 2 divided doses; max. 16 mg daily.
Dose adjustment:
Renal impairment: CrCl > 30 ml/min, initially 2 mg/day, max. 8 mg/day.
Geriatric: 4 mg in 1-2 divided doses; caution with doses >8 mg daily.
Contraindication:
History of ACE-inhibitor induced angioedema.
Adverse effect:
Common: hypotension, hyperkalemia, nausea, dizziness, cough.
Serious: intestinal angioedema, liver failure, angioedema.