Psychopharmacologic Drugs : Antipsychotics
OTOPI1 “Topimo tablet” 2 mg/tab
適應症：精神病狀態。
Usual dose:
Tourette’s disorder:
Adult: initial, 1-2 mg/day in divided doses; increase dosage gradually qod; max. 10 mg/day or 0.2 mg/kg/day.
Pediatric (≧12 yrs): initial, 0.05 mg/kg/day hs; the dosage may be increased q3d; max. 10 mg/day or 0.2 mg/kg/day.
Dose adjustment:
Reduction of dose is necessary in p’ts with liver disease.
Adverse effect:
Common: hypotension, orthostatic hypotension, diminished sweating, photosensitivity, constipation, xerostomia, akathisia, dizziness, drug-induced tardive dystonia, dystonia, extrapyramidal disease, Parkinsonian, somnolence, tardive dyskinesia, blurred vision, epithelial keratopathy, eye/vision finding, retinitis pigmentosa, urinary retention, nasal congestion.
Serious: prolonged QT interval, torsades de pointes, obstipation, paralytic ileus, agranulocytosis, disorder of hematopoietic structure, leukopenia, thrombocytopenia, cholestatic jaundice syndrome, drug-induced lupus erythematosus, systemic, ineffective thermoregulation, heatstroke or hypothermia, neuroleptic malignant syndrome, seizure, priapism.