Hormones and Agents Affecting Hormonal Mechanism: Thyroid Disorders
OPOLU1 “Polupi tablet” 50 mg/tab
適應症：甲狀腺機能亢進症。
Usual dose:
Hyperthyroidism:
Adult: initial, 300-400 mg/day in divided doses q8h; (occasionally initial doses as high as 600-900 mg/day are necessary); maintenance, 100-150 mg/day in divided doses q8-12h.
Pediatric
(6-10 yrs): initial, 50-150 mg/day or 5-7 mg/kg/day in divided doses q6-8h.
(> 10 yrs): initial, 150-300 mg/day or 5-7 mg/kg/day in divided doses q6-8h; maintenance, 50 mg PO bid or 1/3-2/3 of the initial dose.
Precaution:
Bleeding disorders or easy bruising, liver disease (anorexia, pruritus, right upper quadrant pain, 3-fold elevation of transaminase levels).
Adverse effect:
Common: rash, leukopenia, fever.
Serious: hepatic necrosis, nephritis.
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