Immunologic Agents : Passive Immunity (Antiserums) : Antiserums from Human Source
IRHO1 “Rho(D) Immune Globulin injection”1500 IU/syringe
適應症：預防因配偶間Rh因子不同而導致之流產及初生兒夭折。
Usual dose:
Postpartum prophylaxis: IM, 1 vial into post-partum mother.
Antenatal prophylaxis: IM 1 vial at 28 wks gestation, followed by 1 more dose within 72 h postpartum if infant is Rh(+).
Dose adjustment:
Hemoglobin < 10 g/dL: ITP, IV 125-200 IU/kg.
Contradiction:
IgA deficiency; potential for IgA antibody development and anaphylactic reactions.
Infants; do not administer to infants when used for the suppression of Rh isoimmunization.
Adverse effect:
Common: injection site pain, nausea, decreased hemoglobin, extravascular hemolysis (mild), backache, dizziness, headache, malaise.
Serious: intravascular hemolysis, anaphylaxis, acute renal failure.
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