Anti-infective Agents : Antituberculosis Agents
OMYCO1 “Mycobutin capsule” 150 mg/cap
適應症：預防免疫抑制病人細胞內禽結核分枝桿菌(MAC, Micobacteria avium Intracellulare Complex)感染，治療肺結核桿菌所引起之感染症。
Usual dose:
HIV infection – Tuberculosis:
150 mg qd or 300 mg 2-3 times/wk in combination with amprenavir, indinavir or nelfinavir.
150 mg 2-3 times/wk in combination with ritonavir.
450-600 mg qd or 600 mg 2-3 times/wk in combination with efavirenz 2-3 times/wk in combination with saquinavir hard-gel or soft-gel capsules or 300 mg qd or 2-3 times/wk in combination with saquinavir soft-gel capsules.
300 mg qd or 300 mg 2-3 times/wk in combination with nevirapine.
Dose adjustment:
Renal failure: CrCl < 30 ml/min, 50% dose reduction.
Adverse effect:
Common: discoloration of skin, rash, diarrhea, disorder of taste, dyspepsia, loss of appetite, nausea, vomiting, increased liver aminotransferase level (mild), ocular discoloration, uveitis.
Serious: anemia, neutropenia, thrombocytopenic disorder, systemic lupus erythematosus.