Cardiovascular – Renal Drugs : Hyperlipidemia
OSIMV1 “Simvatin FC tablet” 20 mg/tab
OZOCO2 “Zocor FC tablet” 40 mg/tab
OZOLO2 “Zolotin FC tablet” 20 mg/tab
適應症：高膽固醇血症、高三酸甘油酯血症；降低冠心病高危險群或冠心病患者的心血管事件發生率，及冠心病致死率；患有異核質家族性高膽固醇血症的兒童病患。
Usual dose:
Hypercholesterolemia, homozygous familial:
Adult: 40 mg every evening; alternatively, 80 mg daily in 3 divided doses (20 mg, 20 mg, & 40 mg (in the evening)).
Pediatric (10-17 yrs): initial, 10 mg daily in the evening; maintenance, 10 to 40 mg daily; max. 40 mg/day.
Hyperlipidemia:
Adult: initial, 20-40 mg every evening; dose range, 5-80 mg/day.
Coronary arteriosclerosis; Prophylaxis:
Adult: initial, 20-40 mg every evening; dose range, 5-80 mg/day.
Cerebrovascular accident, diabetes mellitus- vascular disorder; Prophylaxis:
Adult: initial, 40 mg hs; dose range, 5-80 mg/day.
Dose adjustment:
Renal impairment: severe renal insufficiency: initial, 5 mg qd with close monitoring.
Coronary heart disease: initial, 40 mg hs; measure lipid levels after 4 wk of therapy; dose range 5-80 mg daily.
Immunosuppression therapy (concomitant cyclosporine) initial, 5 mg qd; maintenance, max. 10 mg/day.
Concomitant amiodarone or verapamil: max 20 mg/day.
Concomitant gemfibrozil, other fibrates, niacin – (≧1g/day): max. 10 mg/day.
Severe renal insufficiency: initial, 5 mg qd with close monitoring.
Contraindication:
Active liver disease or elevated liver enzymes (persistent, unexplained), pregnancy and lactation.
Adverse effect:
Common: constipation, GI upset, headache.
Serious: hepatotoxicity, myalgia, myopathy, rhabdomyolysis.
健保使用規範：同acipimox。