Anti-infective Agents : Aminoglycosides
ISTRE1 “Streptomycin injection” 1 gm/vial
適應症：結核菌感染症、結核性腦脊髓膜炎、急性血行性粟粒結核、咽頭及喉頭結核症、氣管及支氣管結核性潰瘍、結核性肉芽增殖、乾骼性肺炎、滲出性肺結核、結核性皮膚穿孔、潰瘍性腸結核、結核性腹膜炎、結核性心內膜炎、眼結核等。
Usual dose: IM
Adult: 1 g q12h, then 500 mg q12h.
Pediatric: 20-40 mg/kg/day divided q6-12h.
TB: IM
Adult: 15 mg/kg/day qd, max. 1 g/day, or 25-30 mg/kg/dose 2-3 times/wk, max. 1.5 gm/dose.
Pediatric: 20-40 mg/kg qd, max. 1 g/day, or 25-30 mg/kg 2-3 times/wk, max. 1.5 gm/day.
Dose adjustment:
Renal failure: change interval, CrCl > 50 ml/min, q24h; CrCl 10-50 ml/min; q24-72h; CrCl < 10 ml/min, q72-96h; hemodialysis: one-half normal dose recommended as supplement after dialysis.
Geriatrics (≧60 yrs): reduced doses.
Adverse effect:
Common: drug-induced eosinophilia, facial paresthesia.
Serious: isease of brain, neuromuscular blockade finding; concomitant anesthesia or muscle relaxants: peripheral neuritis, disorder of optic nerve, disorder of inner ear, nephrotoxicity, concomitant anesthesia.