Thalidomide【X】

Antineoplastic Agents: Miscellaneous

OTHAD1 “Thado capsule” 50 mg/cap

適應症：痲瘋性結節紅斑（Erythema nodosum leprosum, ENL)，可用於中度至重度ENL出現皮膚徵兆之急性期治療，亦可持續用於預防及抑制ENL皮膚徵兆復發，不可單獨用於治療發生中度至重度神經炎之ENL。

Usual dose:

Initial, 100-300 mg PO hs or > 1 h after meals; max. 400 mg/day (may be given in divided doses).

Adverse effect:

Common: dizziness, drowsiness, somnolence, rash.

Serious: deep vein thrombophlebitis, pulmonary embolism, thrombophlebitis, thrombosis, infection, leukopenia (in HIV seropositive p’ts), orthostatic hypotension, Steven’s Johnson syndrome, toxic epidermal necrolysis, teratogenicity.

健保使用規範：治療新診斷多發性骨髓瘤。使用時須和prednisolone及oral melphalan併用，或和骨髓移植併用，或和palmidronate併用於骨髓移植後之治療(98/7/1)。