Psychopharmacologic Drugs : Antipsychotics
OFLUR1 “Flurazin FC tablet” 5 mg/tab
適應症：精神病狀態、噁心、嘔吐、攻擊性與破壞性之行為障礙。
Usual dose:
Anxiety, Non-psychotic:
Adult: 1-2 mg bid; do not administer max. 6 mg/day, < 12 wks.
Schizophrenia:
Adult: 2-5 mg bid; usual effective dosage is 15-20 mg/day, max. 40 mg/day.
Pediatric (6-12 yrs): 1 mg qd-bid; may increase dosage gradually as needed to a max. 15 mg/day.
Dose adjustment:
Geriatric, liver disease: lower initial dose and more gradual dosage titration.
Contraindication:
Blood dyscrasias, bone marrow depression, coma or concomitant use of large doses of other CNS depressants, pre-existing liver damage.
Adverse effect:
Common: hypotension, orthostatic hypotension, diminished sweating, photosensitivity, constipation, xerostomia, akathisia, dizziness, drug-induced tardive dystonia, dystonia, extrapyramidal disease, parkinsonian, somnolence, tardive dyskinesia, blurred vision, epithelial keratopathy, eye/vision finding, retinitis pigmentosa, urinary retention, nasal congestion.
Serious: prolonged QT interval, torsades de pointes, obstipation, paralytic ileus, agranulocytosis, disorder of hematopoietic structure, leukopenia, thrombocytopenia, cholestatic jaundice syndrome, drug-induced lupus erythematosus, ineffective thermoregulation, heatstroke or hypothermia, neuroleptic malignant syndrome, seizure, priapism, death.