Hematological Agents : Anticoagulants
OCOFA1 “Cofarin tablet” 1 mg/tab
OCOFA5 “Cofarin tablet” 5 mg/tab
適應症：
OCOFA1：靜脈栓塞症。
OCOFA5：1.預防及/或治療靜脈栓塞症及相關疾病，以及肺栓塞。2.預防或治療因心房纖維顫動及/或更換心臟瓣膜引起之血栓性栓塞症。
Usual dose:
Adult: initial, 2-5 mg qd; maintenance, 2-10 mg qd.
Contraindication:
Abortion, alcoholism, anesthesia, aneurysms, bacterial endocarditis, blood dyscrasias, cerebrovascular hemorrhage, malignant hypertension, pericarditis; surgery of central nervous system or eye, recent or potential; bleeding tendencies of the gastrointestinal, genitourinary, or respiratory tract.
Precaution:
Vitamin K deficiency, diarrhea, edema (may increase PT/INR response).
Adverse effect:
Serious: hemorrhage, purple toes syndrome, hepatitis, necrosis of skin and other tissues, hypersensitivity reactions, cholesterol embolization.
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