Anti-infective Agents : Cephalosporins : First Generation Cephalosporins
OCEPH2 “Cephalexin capsule” 500 mg/cap
OULEX1 “Ulexin capsule” 500 mg/cap
適應症：葡萄球菌、鏈球菌、肺炎雙球菌、腦膜炎球菌，及其他具有感受性細菌引起之感染症。
Usual dose:
Adult: 250 mg q6h; dose range, 250 mg- 1 g q6h.
Cystitis, uncomplicated, Skin/skin structure infections, Streptococcal pharyngitis:
Adult: 500 mg q12h.
Mild/moderate infections:
Pediatric: 25-50 mg/kg/day divided q6h; max. 4 g/day.
Severe infections:
Pediatric: 50-100 mg/kg/day divided q6h.
Otitis media:
Pediatric: 75-100 mg/kg/day divided q6h.
Dose adjustment:
Renal failure: CrCl < 50 ml/min, usual dose q12 h.
Contraindication:
Oncurrent administration of calcium-containing IV solutions, including continuous calcium-containing infusions such as parenteral nutrition, in neonates aged 28 days or less due to risk of fatal salt precipitation in lungs and kidneys.
Hyperbilirubinemic neonates, due to increased risk of bilirubin encephalopathy (kernicterus), especially in premature neonates.
Hypersensitivity to cephalosporins.
Adverse effect:
Abdominal pain, diarrhea, transient elevation in liver enzymes.