Hormones and Agents Affecting Hormonal Mechanism: Estrogens, Progestins, Contraceptives and Related Agents
OC1 “Contraceptive 1 tablet”
棕色: levonorgestrel 0.05 mg, ethinylestradiol 0.03 mg
白色: levonorgestrel 0.075 mg, ethinylestradiol 0.04 mg
黃色: levonorgestrel 0.125 mg, ethinylestradiol 0.03 mg
OC2 “Contraceptive 2 tablet”
黃色: levonorgestrel 0.15 mg, ethinylestradiol 0.03 mg
OC3 “Contraceptive 3 tablet”
橘色: levonorgestrel 0.25 mg, ethinylestradiol 0.05 mg
適應症：避孕藥。
Usual dose: PO
Monophasic combined OC: As tab containing levonogestrel 150-250 mcg and ethinylestradiol 30 mcg: 1 tab qd.
Triphasic combined OC: Levonorgestrel 50-125 mcg and ethinylestradiol 30-40 mcg: 1 tab qd.
Contraindication: See Estrogen Conjugated.
Adverse effect:
Common: breast discomfort; gynaecomastia; depression; disturbance of appetite; wt changes; fluid retention; oedema; changes in libido; hair loss or hirsutism; genitourinary changes; haematologic disorders; endocrine and metabolic disorders; cholestatic jaundice; chorea; contact lens intolerance; steeping of corneal curvature; pulmonary thromboembolism; carbohydrate and/or glucose intolerance; depression; chloasma; BP increase, liver impairment; reduced menstrual loss, spotting’ in early cycles, absence of withdrawal bleeding; rarely photosensitivity; increased risk in breast cancer; elevation of plasma bound iodine, cortisol and thyroid binding, erythrocyte sedimentation may be accelerated; increases in plasma copper, iron and alkaline phosphatase; may affect serum triglyceride and lipoprotein levels; retinal vascular thrombosis.
Serious: Hepatic tumours; increased risk of thromboembolism.