Psychopharmacologic Drugs : Affective Disorders
OSINZ1 “Sinzac capsule” 20 mg/cap
適應症：抑鬱症、暴食症、強迫症。
Usual dose:
Major depressive disorder:
Adult: initial, 20 mg qd in the morning; maintenance, max. 80 mg/day or 90 mg qw.
Pediatric ( > 8 yrs): 10-20 mg qd.
Bulimia nervosa:
Adult: 60 mg qd am.
Obsessive-compulsive disorder:
Adult: initial, 20 mg qd am; maintenance, 20-60 mg/day, max. 80 mg/day.
Pediatric (> 7yrs): initiate at 10 mg qd; may increase to 20 mg qd after 2 wks; dose range 20-60 mg/day (higher weight), 20-30 mg/day (lower weight).
Dose adjustment:
Liver disease, Geriatric: a lower initial dose or longer dosing interval.
Contraindication:
Concomitant use of MAOIs, pimozide, or thioridazine.
Adverse effect:
Hypersensitivity reactions including rash, anxiety, nervousness, insomnia, anorexia, weight loss, asthenia, GI disturbances, somnolence, tremor, pharyngitis, sweating, impotence, abnormal ejaculation, mania or hypomania.
健保給付規範：
1.2.1.選擇性血清促進素再吸收抑制劑 (SSRI)、血清促進素及正腎上腺素再吸收抑制劑 (SNRI)及其他抗憂鬱劑（fluvoxamine maleate、fluoxetine、paroxetine、sertraline、venlafaxine、milnacipran、mirtazapine、citalopram、escitalopram、duloxetine、agomelatine等製劑）：(88/12/1、89/10/1、91/5/1、92/6/1、93/5/1、94/2/1、94/12/1、99/10/1、101/7/1)使用時病歷上應詳細註明診斷依據及使用理由。