Neurologic Drugs : Antiepileptics
ONEUR1 “Neurontin capsule” 300 mg/cap
OREMA1 “Remaltin oral solution” 50 mg/ml; 240 ml/bot
適應症：治療成人及三歲以上兒童局部癲癇發作之輔助療法。帶狀疱疹後神經痛。
Usual dose:
Postherpetic neuralgia:
Adult: 300 mg on Day 1, 300 mg bid on Day 2, and 300 mg tid on Day 3; may increase dosage up to 1800 mg/day (divided into 3 doses), dosage up to 2400 mg/day have been well tolerated.
Partial seizure; adjunct:
Adult (≧12 yrs): 300 mg tid; may increase up to 1800 mg/day (divided into 3 doses).
Pediatric
(3-12 yrs): initial, 10-15 mg/kg/day in 3 divided doses.
(3-4 yrs): maintenance, titrate over 3 days to 40 mg/kg/day in 3 divided doses.
(5-12 yrs): maintenance, titrate over 3 days to 25-35 mg/kg/day in 3 divided doses.
Dose adjustment:
Renal impairment:
|
CrCl (ml/min) |
Dose (mg/day) |
|
> 60 |
900-3600 |
|
30-59 |
400-1400 |
|
15-29 |
200-700 |
|
15 |
100-300 |
|
< 15 |
reduce in proportion to CrCl |
Adverse effect:
Common: peripheral edema, myalgia, ataxia, dizziness, hyperactive behavior, nystagmus, somnolence, tremor, disorder of form of thought, hostile behavior, mood swings.
Serious: Stevens-Johnson syndrome, seizure.
健保使用規範：
1.限用於其他抗癲癇藥物無法有效控制之局部癲癇發作之輔助性治療(add on therapy)。(89/9/1、89/2/1、93/6/1、96/3/1、97/1/1、97/10/1、101/2/1)
2.限使用於帶狀疱疹皮膚病灶後神經痛，並符合下列條件：(1)使用其他止痛劑或非類固醇抗發炎劑（NSAIDs）藥品治療後仍無法控制疼痛或有嚴重副作用者；(2)限每日最大劑量為3,600 mg，且日劑量超過2,400 mg時，須於病歷記載理由。臨床症狀改善，應逐步調低劑量。(97/12/1、98/4/1、98/9/1、101/5/1)