Anti-infective Agents : Antiretroviral Agents
ICYME1 “Cymevene Lyophilized IV injection” 500 mg/vial
適應症：用於治療免疫功能缺乏之巨細胞病毒感染症。
Usual dose:
Cytomegaloviral retinitis:
Adult: induction, 5 mg/kg q12h for 14-21 days; maintenance, 5 mg/kg qd 7 days/wk, or 6 mg/kg qd 5 days/wk.
Recurrence; prophylaxis – HIV infection:
Adult: 5 mg/kg qd 7 days/wk, or 6 mg/kg IV qd 5 days/wk.
Dose adjustment:
Renal failure:
Induction dose: CrCl 50-69 ml/min, 2.5 mg/kg q12h; CrCl 25-49 ml/min, 2.5 mg/kg q24h; CrCl 10-24 ml/min, 1.25 mg/kg q24h; CrCl < 10 ml/min, 1.25 mg/kg 3 times/wk following hemodialysis
Maintenance dose: CrCl 50-69 ml/min, 2.5 mg/kg q24h; CrCl 25-49 ml/min, 1.25 mg/kg q24h; CrCl 10-24 ml/min, 0.625 mg/kg q24h; CrCl < 10 ml/min, 0.625 mg/kg 3 times/wk following hemodialysis.
Contraindication: p’ts with severe neutropenia (ANC < 500/mcL) or severe thrombocytopenia (platelets < 25,000/mcL).
Adverse effect:
Phlebitis, loss of appetite, anemia, neutropenia, thrombocytopenic disorder, fever.