Gastrointestinal Agents : Laxatives
ODUPH6 “Duphalac syrup” 666 mg/ml; 300 ml/bot
OLACT3 “Lactul syrup” 666 mg/ml; 60 ml/bot
適應症：患病期慢性便秘、門系肝腦病變、肝昏迷前期、肝昏迷。
Usual dose:
Constipation:
Adult: 15-45 ml tid-qid for 24-48 h; max. 40 gm/day.
Pediatric
(infants): 2.5-10 ml/day (20 gm/30 ml) in 3-4 divided doses.
(children): 40-90 ml/day (20 gm/30 ml) in 3-4 divided doses.
Hepatic encephalopathy: PO/Rectal
Adult: initial, PO 30-45 ml tid-qid, then adjusted q1-2 day to achieve 2-3 soft formed stools/day or 300 ml mixed with 700 ml of water or saline Rectally as a retention enema (retain for 30-60min) q4-6h as needed.
Precaution: diabetes.
Adverse effect:
Common: bloating symtom, cramping, diarrhea, nausea, vomiting, epigastric pain, flatulence.
Serious: hypernatremia, hypokalemia.
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