Anti-infective Agents : Antiviral Agents
OZEFF1 “Zeffix tablet” 100 mg/tab
適應症：治療患有慢性Ｂ型肝炎且帶有Ｂ型肝炎病毒複製跡象之患者。
Usual dose:
Type B viral hepatitis, chronic:
Adult: 100 mg qd.
Pediatric (2-17 yrs): 3 mg/kg qd, max. 100 mg/day.
Dose adjustment:
Renal failure: (HBV infection) CrCl 30-49 ml/min, 100 mg first dose then 50 mg qd; CrCl 15-29 ml/min, 100 mg first dose then 25 mg qd; CrCl 5-14 ml/min, 35 mg first dose, then 15 mg qd; CrCl < 5 ml/min, 35 mg first dose then 10 mg qd.
Adverse effect:
Common: lipodystrophy, decrease in appetite, nausea, vomiting, headache, fatigue.
Serious: lactic acidosis, pancreatitis, especially children, hepatomegaly, relapsing type B viral hepatitis.
健保使用規範：同baraclude 0.5 mg。
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