Cardiovascular – Renal Drugs : Antihypertensive : Sympathetic Depressants
OBETA2 “Betaloc ZOK tablet” 95 mg/tab
適應症：高血壓、心絞痛、慢性心衰竭；在心肌梗塞之急性期後，預防心肌之死亡，及再梗塞、心律不整。
Usual dose:
Angina:
Adult: initial 100 mg qd, may titration dose gradually at wk intervals; maintenance, 100-400 mg qd.
Congestive heart failure:
Adult: (NYHA class II) initial, 25 mg qd for 2 wks; (NYHA class III-IV) initial, 12.5 mg qd for 2 wks, titration, dose may be doubled q2w to highest tolerated dose or up to 200 mg qd.
Hypertension:
Adult: initial, 25-100 mg qd, titration, allow 1-2 wks to achieve optimum antihypertensive effect; maintenance, 100-400 mg qd.
Pediatric (≧6 yrs): initial, 1 mg/kg qd, max. 50 mg qd; adjust dose based on clinical response.
Contraindication:
Bradycardia(severe), cardiac failure(decompensated), cardiogenic shock, heart block (second and third degree), sick sinus syndrome.
Precaution:
Bronchospastic disease, concomitant use with calcium channel blockers; may significantly affect the heart rate or rhythm.
Diabetes mellitus; possibility of masked hypoglycemia
Liver disease, thyrotoxicosis; may mask clinical signs of hyperthyroidism, such as tachycardia.
Adverse effect:
Common: bradycardia, hypertension, heart failure, pruritus, rash, poor glycemic control, diarrhea, nausea, constipation, arthralgia, tiredness and dizziness, depression, wheezing, dyspnea,
Serious: bronchospasm.
健保使用規範：限用於慢性心衰竭病患。(93/5/1)