Gastrointestinal Agents : Agents Used in Peptic Ulcer Disease : Proton Pump Inhibitor
IPANE1 “Pane injection”40 mg/vial
IPANT2 “Pantoloc injection”40 mg/vial
OPANH1 “PanHo tablet”40 mg/tab
OPANT2 “Pantoloc tablet”40 mg/tab
[泡法]
(1) 5 amp in N/S 500 ml run 20 ml/hr
(2) 2 amp in N/S 100 ml run 10 ml/hr
[備註]
(1) For stress ulcer
(2) 健保給付high dose PPI 3天
適應症：合併二種適當之抗微生物製劑治療與幽門螺旋桿菌相關之消化性潰瘍、胃潰瘍、十二指腸潰瘍、中度及嚴重胃食道逆流性疾病、Zollinger-Ellison Syndrome。
Usual dose:
Duodenal ulcer disease: PO, 40-80 mg qd for 4-8 wks.
Erosive esophagitis associated with gastroesophageal reflux disease: PO, 40 mg qd.
Gastric hypersecretion, pathological:
IF, 80 mg q12h, can increase to q8h, max. 240mg/day.
PO, 40 mg bid, max. 240 mg/day.
Helicobacter pylori gastrointestinal tract infection (triple therapy) : 40 mg bid in combination with amoxicillin 1 gm bid and clarithromycin 500 mg bid for 10-14 days.
Zollinger-Ellison syndrome: IV/PO
80 mg IV q12h, can increase to q8h, max. 240 mg/day; 40 mg PO bid, max. 240 mg/day.
Contraindication:
Hypersensitivity reactions, including anaphylaxis, anaphylactic
shock, angioedema, bronchospasm, acute interstitial nephritis,
and urticaria, to any component of this product or to any
substituted benzimidazole.
Precaution:
Dissolved with 10 ml NS, then adds to 100 ml of D5W or NS for IV infusion or direct IV, infuse over 2-15 min. Reconstituted solution must be used within 12 h.
Adverse effect:
Common: diarrhea, headache, abdominal pain, flatulence.
Serious: atrophic gastritis, thrombocytopenia, Stevens-Johnson syndrome, toxic epidermal necrolysis, disorder of muscle, hip fracture, rhabdomyolysis.
健保使用規範：同aluzaine。