Hormones and Agents Affecting Hormonal Mechanism: Estrogens, Progestins, Contraceptives and Related Agents
OPROM1 “Promone soft capsule” 100 mg/cap
適應症：口服途徑給藥：婦科：黃體素不足造成失調，主要為：經前症候群，因異常排卵或停止排卵引起的經期不規則。良性乳腺病，停經前期症狀。更年期治療（雌激素療法的輔助藥品）。黃體期障礙造成不孕。產科：預防黃體期障礙造成習慣性流產。陰道途徑給藥：因黃體期障礙引起初級或次級不孕（主要用於：排卵困難，做人工受孕或卵子捐贈時的黃體期補充。）預防黃體期障礙造成習慣性流產。
Usual dose:
Abnormal uterine bleeding unrelated to menstrual cycle: 5-10 mg IM daily for 6 doses.
Endometrial hyperplasia; Prophylaxis: 200 mg PO at bedtime for 12 sequential days per 28-day cycle to postmenopausal women with a uterus who are receiving daily conjugated estrogens.
Dose adjustment:
Progesterone is contraindicated in severe liver disease or dysfunction.
If menses starts during the course of progesterone injections, the drug should be discontinued.
Contraindication:
Breast cancer, cerebral apoplexy, genital cancer, liver disease, missed abortion, thromboembolic disorders, thrombophlebitis, undiagnosed abnormal vaginal bleeding.
Precaution:
Progesterone is contraindicated in patients allergic to peanuts (as the capsules contain peanut oil).
Progesterone is contraindicated for use in known or suspected pregnancy, as a diagnostic test for pregnancy, missed abortion, undiagnosed vaginal bleeding, and in severe liver dysfunction or disease.
Progesterone is also contraindicated in patients with thrombophlebitis, thromboembolic disorders, cerebral apoplexy or patients with a past history of these conditions. If early manifestations of these disorders occur, progesterone should be discontinued immediately.
Progesterone should be discontinued if there is sudden partial or complete loss of vision, or if there is a sudden onset of proptosis, diplopia or migraine, or if examination reveals papilledema or retinal vascular lesions. Patients should report immediately to their doctors any changes in vision.
Adverse effect:
Common: abdominal pain, constipation, nausea, viral disease, cramp, dizziness, headache, sleep disorder, somnolence, breast tenderness, depression.
Serious: cerebrovascular accident, myocardial infarction, thrombophlebitis, cholecystectomy, breast cancer, excisional biopsy of breast, thrombosis of retinal artery, venous thromboembolism, dementia, ectopic pregnancy, pulmonary embolism, breast cancer.