00_Featured_Images - physical_examination_featured.jpg

作者/講者: 王喬弘 醫師

整理:  陳羿方 醫師

校稿: Ian YC Chen, MD

上次校閱: 2019/02/25

A more precise classification of the patient’s symptoms is helpful in the differential diagnosis. There are multiple criteria to be considered:

(1) Temporal

♥ acute onset, vs. chronic (present for more than four weeks), vs. acute worsening of pre-existing symptoms

intermittent vs. permanent

episodic (attacks)

(2) Situational

at rest

on exertion

accompanying emotional stress

depending on body position

depending on special exposure(s)

(3) Pathogenetic

problems relating to the respiratory system (central control of breathing, airways, gas exchange)

problems relating to the cardiovascular system

mixed cardiac and pulmonary causes

other causes, e.g., anemia, thyroid disease, poor physical condition (i.e., muscle deconditioning)

mental causes

The diagnosis and treatment of dyspnea are sometimes made more difficult by the simultaneous presence of more than one underlying disease, particularly in elderly, multimorbid patients.

Ref: The Differential Diagnosis of Dyspnea

Dominik Berliner, Nils Schneider, Tobias Welte, Johann Bauersachs, Dtsch Arztebl Int. 2016 Dec; 113(49): 834–845. 

病人如果走 15-30 meters (50-100 feet) 就會喘,通常都有急性肺微血管楔型壓升高 (elevated pulmonary capillary wedge pressure) 或是肺動脈高壓 (pulmonary hypertension)。而運動引發之 asthma 常常需要更高強度的運動約 3 分鐘後發生,在 10~15 分鐘內達到高峰。


(1) 突然的劇痛:有可能是因為發生氣胸、肺栓塞,主動脈剝離,急性心肌梗塞

(2) 發燒,黃痰 (可能是感染)

(3) 體重減輕,咳血:可能是腫瘤或結核造成

在問完病史後,有了初步的 differential diagnoses 後,通常可進一部安排相關檢查,包括胸部 X 光、動脈血、常規血液、心電圖、肺功能等檢查 (佐證你的想法,切忌一開始就採取亂槍打鳥式的做法)。

Symptoms and signs accompanying dyspnea that may be of differential diagnostic significance
Additional symptoms and signs Differential diagnostic considerations
Bradycardia SA or AV block, overdose of drugs that slow the heart rate
Brainstem signs, neurologic deficits brain tumor, cerebral hemorrhage, cerebral vasculitis, encephalitis
Cough nonspecific; mainly reflects diseases affecting the airways and the lung parenchyma
Cyanosis respiratory failure (acute) heart defect with right-to-left shunt, Eisenmenger syndrome (chronic)
Diminished or absent breathing sounds COPD, severe asthma, (tension) pneumothorax, pleural effusion, hematothorax
Distention of the neck veins
with rales in the lungs acutely decompensated congestive heart failure, acute respiratory failure
with normal auscultatory findings pericardial tamponade, acute pulmonary arterial embolism
Dizziness, syncope valvular heart disease (e.g., aortic valvular stenosis), hypertrophic or dilated cardiomyopathy, marked anemia, anxiety disorder, hyperventilation
Exhaustion, generalized weakness, exercise intolerance, muscle weakness anemia, collagenoses, malignant disease (e.g., lung cancer), neuromuscular disease
Fever pulmonary infection, e.g., pneumonia or acute bronchitis, exogenous allergic alveolitis, thyrotoxicosis
Heart murmur cardiac valvular disease
Hemodynamic dysfunction:
hypertensive hypertensive crisis, panic attack, acute coronary syndrome
hypotensive forward heart failure, metabolic disturbance, sepsis, pulmonary arterial embolism
Hemoptysis lung cancer, pulmonary embolism, bronchiectasis, chronic bronchitis, tuberculosis
Hepatojugular reflux acutely decompensated congestive heart failure
Hoarseness disease of the glottis or trachea, recurrent laryngeal nerve palsy
Hyperventilation acidosis, sepsis, salicylate poisoning, psychogenic (incl. anxiety)
Impairment of consciousness psychogenic hyperventilation, brain disease, metabolic disturbance, pneumonia
Orthopnea acute congestive heart failure, toxic pulmonary edema
on respiration pneumothorax, pleuritis/pleuropneumonia, pulmonary embolism
independent of respiration myocardial infarction, aortic aneurysm, Roemheld syndrome, renal or biliary colic, acute gastritis
Pallor marked anemia
Paradoxical pulse right-heart failure, pulmonary arterial embolism,cardiogenic shock, pericardial tamponade, exacerbation of bronchial asthma
Peripheral edema congestive heart failure
Platypnea hepatopulmonary syndrome, intrapulmonary shunting
Rales pneumonia, acutely decompensated congestive heart failure, acute respiratory failure
inspiratory croup, foreign body, bacterial tracheitis
expiratory/combined foreign body, epiglottitis, angioedema
Urticaria Angioedema
Use of auxiliary muscles of respiration (acute) respiratory failure, severe COPD, severe asthma
Vegetative symptoms (trembling, cold sweat, etc.) respiratory failure, anxiety disorder, acute myocardial infarction
Wheezes (exacerbation of) bronchial asthma, COPD, acutely decompensated congestive heart failure, foreign body

(1) 胸部緊、悶的感覺可能是由於氣喘病或者心絞痛造成。心絞痛的痛可能傳到左肩或下巴,也可能會有合併冒冷汗之現象。

(2) 覺得需要用力才喘得起來(呼吸道阻塞或者神經肌肉疾病或者肺部或胸壁彈性變差的問題 )

(3) 當躺下或者坐著時會比較容易呼吸困難;前者較像是心臟或者肺部之問題

♥ Inspection

Inspect patient, comment on respiratory status, conjunctiva (pale or not).

State that weight should be measured for BMI/fluid overload status.

Volume Status

Examine lower extremities for pitting edema.

Examine JVP and comments on its estimated height.

Measure pulse, comments on rate and rhythm.

Evaluate patient’s orthostatic vitals.

Examine the abdomen for ascites and a pulsatile liver, indicating right heart failure.

♥ Pre-cordium/Carotid

Palpate for the presence of thrills, heaves.

Palpate PMI and comments on size, amplitude, duration, and location.

Auscultate in all 4 areas of precordium with bell and diaphragm.

Comment on presence of murmurs, extra heart sounds.

Examine carotid arteries for bruits.

♥ Respiratory

Percusse posterior chest, comment on dullness.

Auscultate all lung fields, commenting on presence of crackles, wheeze or other adventitious breath sounds.

如果到 paradoxical 就是快呼吸衰竭了

Chest X-ray interpretation

Confirm details

Image quality: 吸氣沒有吸飽

Airway、Breathing、Cardiac、Diaphragm、Everything else

Ref: https://geekymedics.com/chest-x-ray-interpretation-a-methodical-approach/




吸氣一樣吸得不好,左下: linear, band like, sputum 卡住

如果大於 72 小時臨床上沒有改善,可能要考慮:

♣ Resistant microorganism

Uncovered pathogen

Parapneumonic effusion/empyema

Nosocomial superinfection

Misdiagnosis: PE, CHF, vasculitis, COP

Drug fever

擔心有沒有 cover 的細菌,可以考慮換抗生素。

VTE 的誘發風險 : 


生活型態:長期不動 (immobilization)、肥胖、男性 (男性也算生活型態?)、高齡。


其中,凝血功能異常包括:抗磷脂質症候群 (antiphospholipid syndrome, APS)、factor V Leiden異常、凝血酶原 (prothrombin) G20210A 基因突變等。

Ref: http://jerryljw.blogspot.com/2016/05/blog-post.html


Based on this article:American College of Chest Physicians (ACCP) Guideline and Expert Panel Report on Antithrombotic Therapy for VTE Disease.

Step 0: confirm diagnosis

Step 1: stratify risk with Pulmonary Embolism Severity Index (PESI)

Step 3: offer PESI-based management

What then is the role of CDT in patients with PE?

We think that current evidence suggests that CDT is preferred to systemic thrombolytic therapy

1.in patients with acute PE who require active thrombus removal and

2.have risk factors for bleeding.

We suggest that venous puncture for CDT should always be ultrasound-guided and that the total dose of thrombolytic drug should be kept to a minimum in patients with a high risk of bleeding . If there is need for active thrombus removal in patients with a very high risk of bleeding, it may be necessary to use catheter-based therapy without thrombolytic drug or to use surgical embolectomy.

We are not ready to encourage use of CDT in preference to anticoagulation alone in stable patients with acute PE and right ventricular dysfunction.

Ref:JACC: Cardiovascular Interventions

Volume 8, Issue 10, August 2015DOI: 10.1016/j.jcin.2015.06.009  Catheter-Directed Thrombolysis for Pulmonary Embolism

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