Anti-infective Agents : Cephalosporins : Third Generation Cephalosporins
ICLAF1 “Claforan injection” 2 gm/vial
適應症：對下列疾病具感受性細菌之感染：下呼吸道感染、泌尿器官感染、生殖器官感染、敗血症、皮膚感染、腹腔感染、骨骼關節炎症、中樞神經系統感染。
Usual dose: IV/deep IM
Adult: 1 g q12h; moderate to severe, 1-2 g q8h; severe and life-threatening, 2 g q4h.
Pediatric
(0-1 wk): 50 mg/kg q12h;
(1-4 wks): 50 mg/kg q8h;
(1 mon to 12 yrs, < 50 kg); 50-180 mg/kg/day divided q4-6h, max. 12 g/day;
(> 12 yrs, > 50kg): 1 g q12h; moderate to severe, 1-2 g q8h; severe, 2 g q4h, max. 12 g/day.
Dose adjustment:
Renal failure: CrCl < 20 ml/min/1.73 m2, reduce dose by 50%.
Adverse effect:
Common: injection site pain or phlebitis, pruritus, rash, diarrhea, disease of GI tract, N&V, hypersensitivity reaction, fever.
Serious: S-J syndrome, agranulocytosis, granulocytosis.
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