Hormones and Agents Affecting Hormonal Mechanism : Anterior Pituitary and Hypothalanic Function
IMENO1 “Menopur injection”equal to FSH 75 IU, LH 75 IU/vial
適應症：男女不孕症。
Usual dose:
Stimulation of the development of multiple follicles (IVF), Ovulation induction: initial, 75 IU IM daily for 7-12 days followed by hCG, 5,000-10,000 Units one day after the last dose of menotropins; treat until indices of estrogen activity are equivalent to or > those of the normal individual; if signs of ovulation are present but pregnancy does not occur, repeat this dosage regime for at least 2 more courses before increasing the dose of menotropins.
Spermatogenesis induction: pretreatment with 5000 Units hCG 3 times weekly is required prior to initiating concomitant therapy with menotropins; continue pretreatment until serum testosterone levels are in the normal range and masculinization is reached (may require 4-6 mon); then initiate therapy with menotropins 75 IU IM 3 times weekly and 2000 Units hCG twice weekly for a minimum of 4 mon; if the p’t has not responded after 4 mon, continue treatment with 75 IU menotropins 3 times weekly or increase dose to 150 IU 3 times weekly, keeping the dose for hCG the same.
Contraindication:
Ovarian cysts or enlargement not due to polycystic ovary syndrome.
Adverse effect:
Common: (Women) tachyarrhythmia, rash, swelling at injection site, abdominal pain, bloating symptom, diarrhea, nausea, vomiting, dizziness, pain, cyst of ovary, hypertrophy of ovary, dyspnea, tachypnea; (Men) gynecomastia, pain.
Serious: (Women) occlusion of artery, venous thrombophlebitis, ectopic pregnancy, ovarian hyperstimulation syndrome, acute respiratory distress syndrome, atelectasis, pulmonary embolism, pulmonary infarction, congenital disease.