Anti-infective Agents : Antiretroviral Agents
OKALE2 “Kaletra soft gel capsule”
Each capsule contains lopinavir 200 mg, ritonavir 50 mg
適應症：治療人類免疫缺乏病毒(HIV)的感染。
Usual dose:
Adult (> 40 kg): 3 cap (133.3 mg/33.3 mg) tid; (therapy-naive p’ts only): 800 mg lopinavir/200 mg ritonavir qd; (therapy-naive or therapy-experienced p’ts): 400 mg lopinavir/100 mg ritonavir bid.
Pediatric (15-40 kg): lopinavir 10 mg/kg & ritonavir 2.5 mg/kg bid.
Contraindication: concomitant use with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, triazolam.
Adverse effect:
Common: lipodystrophy, diarrhea, nausea, asthenia, headache.
Serious: hypertriglyceridemia, serum cholesterol raised, diabetes mellitus, exacerbation of diabetes mellitus, hyperglycemia, pancreatitis, hepatotoxicity.
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